Asymmetric synthesis of ent-anorisol A and its stereoisomers and confirmation of the absolute configuration of anorisol A isolated from Anogeissus rivularis

Rungrawin Chatpreecha, Chutima Kuhakarn, Pawaret Leowanawat, Vichai Reutrakul, Darunee Soorukram* We have reported the asymmetric synthesis of three tetrahydrofuran (THF) lignans, namely (2S,3S,4R,5S)-, (2S,3S,4R,5R)-, and (2R,3S,4R,5R)-2-(2,4-dihydroxyphenyl)-5-(4-methoxyphenyl)-3,4-dimethyltetrahydrofurans, which are stereoisomers of natural anorisol A isolated from Anogeissus rivularis. The relative stereochemistry across the THF ring of each of the synthesized THF lignans was readily constructed with high yield and high stereoselectivity … Continue reading Asymmetric synthesis of ent-anorisol A and its stereoisomers and confirmation of the absolute configuration of anorisol A isolated from Anogeissus rivularis